iNOS expression in CD4+ T cells limits T-reg induction by repressing TGF-1: combined iNOS inhibition and T-reg depletion unmask endogenous anti-tumor immunity RUNNING TITLE: iNOS in CD4+ T cells limits T-reg induction by repressing TGF AUTHORS:
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TITLE: iNOS expression in CD4+ T cells limits T-reg induction by repressing TGF-1: combined iNOS inhibition and T-reg depletion unmask endogenous anti-tumor immunity RUNNING TITLE: iNOS in CD4+ T cells limits T-reg induction by repressing TGF
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iNOS expression in CD4+ T cells limits Treg induction by repressing TGFβ1: combined iNOS inhibition and Treg depletion unmask endogenous antitumor immunity.
PURPOSE Expression of inducible nitric oxide synthase (iNOS) in different cellular compartments may have divergent effects on immune function. We used a syngeneic tumor model to functionally characterize the role of iNOS in regulation of CD4(+)FOXP3(+) regulatory T cells (Treg), and optimize the beneficial effects of iNOS inhibition on antitumor immunity. EXPERIMENTAL DESIGN Wild-type (WT) or...
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Tumor growth promotes the expansion of CD4+CD25+ regulatory T (T reg) cells that counteract T cell-mediated immune responses. An inverse correlation between natural killer (NK) cell activation and T reg cell expansion in tumor-bearing patients, shown here, prompted us to address the role of T reg cells in controlling innate antitumor immunity. Our experiments indicate that human T reg cells exp...
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تاریخ انتشار 2014